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Heterologous DNA-rAd prime-boost regimens. (A) Naïve mice and (B) mice with anti-Ad5 immunity were primed at week 0 with 50 μg plasmid DNA vaccine expressing Gag-Pol-Nef and then boosted at week 4 with 109 vp rAd5-Gag, rAd35-Gag, or rAd11-Gag. Gag-specific CD8+ T-lymphocyte responses were assessed by Db/AL11 tetramer binding assays following the boost immunization. The rAd5-Gag boost responses are depicted in the open circles.
