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Cross-reactive Ad35/Ad11-specific immunity. Mice with (A) anti-Ad35 immunity or (B) anti-Ad11 immunity were immunized with 109 vp rAd5-Gag, rAd35-Gag, or rAd11-Gag. Gag-specific CD8+ T lymphocyte responses were assessed by Db/AL11 tetramer binding assays. The rAd5-Gag responses are depicted in the open circles.
