Skip to main content
. 2025 Jan 29;17(3):459. doi: 10.3390/cancers17030459
AKT protein kinase B
AXL anexelekto
ABCB1 ATP-binding cassette subfamily B member 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
BCL-2 B-cell lymphoma 2
BIM Bcl-2 Interacting Mediator of Cell Death
C797S cysteine 797 to serine (mutation in EGFR)
CDK4/6 cyclin-dependent kinases 4 and 6
CEP7 chromosome enumeration probe 7
CNS central nervous system
CTNNB1 catenin beta 1
CAFs cancer-associated fibroblasts
cGAS–STING cyclic GMP-AMP synthase–stimulator of interferon genes
c-MET mesenchymal–epithelial transition factor
EGFR epidermal growth factor receptor
EMT epithelial–mesenchymal transition
ERK extracellular signal-regulated kinase
EMT-TFs epithelial–mesenchymal transition transcription factors
FGFR1 fibroblast growth factor receptor 1
FOXP forkhead box P
GSK-3β glycogen synthase kinase 3 beta
HER2 human epidermal growth factor receptor 2
HER3 human epidermal growth factor receptor 3
HGF hepatocyte growth factor
HER3-DXd HER3-directed DXd conjugate
IGF1R insulin-like growth factor 1 receptor
IL-6 interleukin 6
IL-12 interleukin 12
JAK Janus kinase
KRAS Kirsten rat sarcoma viral oncogene homologue
L792H leucine 792 to histidine (mutation in EGFR)
MAPK mitogen-activated protein kinase
MERTK proto-oncogene tyrosine-protein kinase MER
MET mesenchymal–epithelial transition factor
MCL1 myeloid cell leukemia 1
NSCLC non-small-cell lung cancer
NRAS neuroblastoma RAS viral oncogene homologue
NOX NADPH oxidase
NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells
ORR overall response rate
OS overall survival
PD-L1 programmed death-ligand 1
PFS progression-free survival
PI3K phosphoinositide 3-kinase
PLK1 polo-like kinase 1
PTEN phosphatase and tensin homologue
PARP poly(ADP-ribose) polymerase
PD-1 programmed cell death protein 1
RAF rapidly accelerated fibrosarcoma
RAS rat sarcoma viral oncogene
RB1 retinoblastoma 1
RTK receptor tyrosine kinase
RT radiation therapy
SMAD2 mothers against decapentaplegic homologue 2
STAT signal transducer and activator of transcription
STAT3 signal transducer and activator of transcription 3
T790M threonine 790 to methionine (mutation in EGFR)
TGFβ transforming growth factor beta
TME tumor microenvironment
TKI tyrosine kinase inhibitor
TAM tumor-associated macrophage
TARO3 tyrosine-protein kinase receptor 3
T-DM1 trastuzumab emtansine
VEGF vascular endothelial growth factor
VEGFR vascular endothelial growth factor receptor
ZEB zinc finger E-box binding homeobox