TABLE 1.
Replication of RSV/IL-4 in BALB/c micea
| Virus | Tissueb | Mean virus titer (log10 PFU/g ± SE) on indicated day postinfection
|
||||
|---|---|---|---|---|---|---|
| 3 | 4 | 5 | 7 | 9 | ||
| wt RSV | NT | 3.8 ± 0.1 | 3.7 ± 0.1 | 3.8 ± 0.1 | 2.2 ± 0.1 | <2.0 |
| L | 4.1 ± 0.1 | 4.6 ± 0.1 | 4.5 ± 0.0 | 2.3 ± 0.1 | 1.8 ± 0.1 | |
| RSV/CAT | NT | 4.0 ± 0.1 | 4.0 ± 0.1 | 5.0 ± 0.0 | ND | ND |
| L | 3.7 ± 0.1 | 4.4 ± 0.1 | 4.7 ± 0.1 | ND | ND | |
| RSV/IL-4 | NT | 4.0 ± 0.1 | 3.7 ± 0.1 | 3.7 ± 0.1 | 2.2 ± 0.2 | <2.0 |
| L | 4.0 ± 0.1 | 4.5 ± 0.1 | 4.7 ± 0.1 | <1.7 | <1.7 | |
a
Mice were infected with 106 PFU of the indicated viruses. On days 3, 4, 5, 7, and 9, five mice per group were killed, nasal turbinates and lungs were removed, and virus titers were quantitated by a plaque assay. The detection limits were as follows: for nasal turbinates; 2.0 log10 PFU/g; for lungs, 1.7 log10 PFU/g. ND, not determined.
b
NT, nasal turbinates; L, lungs.