FIG. 7.

Duration of protection offered through transfer of CMV-immune T cells. (A) Following adoptive transfer of MCMV-immune splenocytes and intracranial challenge with MCMV, viral DNA load in the brain assessed by real-time PCR progressively declined throughout the study period and corresponded to clearance of active infection 7 days following reconstitution and remaining latent through the 28-day study endpoint. (B) Splenic repopulation and T-cell proliferation following reconstitution. The percentage of total splenocyte population identified as CD4⁺ T cells (black bars) and CD8⁺ cells (gray bars). n, number of mice per group.