TABLE 2.
Clonal analysis of viral populations by K65R-selective PCR in plasma at baseline, W4, and W12 from five patients undergoing virologic failure
| Patient | No. of K65R mutant clones/total no. of PCR-tested clonesa (% K65R mutant clones)
|
||
|---|---|---|---|
| Baseline | W4 | W12 | |
| 10 | 0/180 (0) | 2b/135 (1.50) | 46/153 (30.0) |
| 12 | 0/122 (0) | 11b/173 (6.35) | 163/163 (100) |
| 16 | 0/170 (0) | 1b/180 (0.55) | 172/178 (96.6) |
| 19 | 0/180 (0) | 82/171 (47.9) | 126/126 (100) |
| 20 | 0/177 (0) | 21/163 (12.9) | 145/173 (83.8) |
a
The denominators indicate the number of clones that were screened by K65R-selective real-time PCR.
b
K65R mutation not detected by bulk sequencing.