Table 4.
Potential VTE risk factors and risk estimates for VTE (definite and probable) based on 4320 women. Comparative assessment with logistic regression analysis: Odds ratio (OR) and 95% confidence interval (95% CI)
| Non-cases | Cases | Crude OR (95% CI) | Adjusted* OR (95% CI) | |||
| Non-exposed | Exposed | Non-exposed | Exposed | |||
| Demographic data | ||||||
| Age: 30+ years vs. <30 | 2830 | 1456 | 13 | 21 | 3.1 (1.6–6.3) | 2.4 (1.1–5.3) |
| BMI: 25+ vs. <25 | 3199 | 1076 | 19 | 15 | 2.3 (1.2–4.6) | 2.0 (0.9–4.1) |
| OC use: ever vs never | 344 | 3941 | 2 | 32 | 1.4 (0.3–5.9) | 1.3 (0.3–5.8) |
| Other hormones: ever vs. never | 4000 | 267 | 31 | 3 | 1.4 (0.4–4.8) | 0.86 (0.2–2.9) |
| Smoking: ever vs. never | 2006 | 2278 | 16 | 18 | 1.0 (0.5–1.9) | 0.8 (0.4–1.7) |
| Medical history | ||||||
| Personal history of VTE: yes vs. no | 4249 | 37 | 30 | 4 | 15.3 (5.1–45.9) | 6.6 (1.8–24.6) |
| Family history of VTE: yes vs. no | 3816 | 470 | 24 | 10 | 3.4 (1.6–7.1) | 2.4 (1.0–5.4) |
| Family history of varicous veins: yes vs. no | 2384 | 1902 | 11 | 23 | 2.6 (1.3–5.4) | 1.9 (0.8–4.1) |
| Family history of MI: yes vs. no | 3804 | 482 | 26 | 8 | 2.4 (1.1–5.4) | 2.0 (0.8–4.6) |
| Family history of stroke: yes vs. no | 3984 | 302 | 29 | 5 | 2.3 (0.9–5.9) | 1.2 (0.4–3.5) |
| Laboratory & genetic markers | ||||||
| FVL mutation§: yes | 4006 | 267 | 29 | 4 | 2.1 (0.7–5.9) | 2.0 (0.7–6.0) |
| Prothrombin mutation§: yes | 4059 | 140 | 29 | 2 | 2.0 (0.5–8.5) | 2.3 (0.5–10.0) |
| Protein C deficiency#: yes | 4087 | 194 | 30 | 4 | 2.8 (0.98–8.0) | 3.0 (0.9–10.4) |
| AT deficiency#:yes | 4073 | 209 | 33 | 1 | 0.6 (0.1–4.3) | 0.5 (0.1–3.5) |
| MTHFR§: yes | 1784 | 2415 | 14 | 17 | 0.9 (0.4–1.8) | 0.95 (0.5–1.97) |
§ homo- and heterozygote together
# definition see methods
* adjusted for all other variables