Figure 1.

Common variation and LD in European Americans at BDKRB2. At the BDKRB2 gene, 22 SNPs with MAF>10% were described for the European American samples (A). Patterns of genotype at each SNP are shown as a visual genotype plot, in which each column represents a site and each row represents a sample. Genotype is color coded, as shown, with SNPs presented in the order they were identified across the gene. Patterns of genotype are clearly similar for many SNPs (e.g., sites 10922 and 12574) but not necessarily for adjacent SNPs. The same data are shown in panel B, with the order of SNPs rearranged such that each SNP is adjacent to SNPs with similar patterns of genotype. Among the 22 SNPs, the LD-based SNP-selection algorithm identified five bins of tagSNPs at an r² threshold of 0.5. tagSNP bins are boxed (B). The LD statistic r² describes the similarity of pattern between pairs of polymorphic sites: pairwise r² between SNPs is shown for the same order of SNPs as in panel B, and bins of SNPs with similar patterns are visible as reddish triangles above the diagonal (C).