Table 5.

Results of the univariable and bivariable Cox proportional hazard regression analyses (adjusted to TNM) for PFS of mRCC patients dependent on distribution of SNP alleles

SNP ID	Progression-free survival
	Univariable Cox analysis			Bivariable Cox analysisc
	HR	95 %–CI	Unadj. p valuea	HR	95 %–CI	Unadj. p valuea	Adj. p valueb
rs699947	0.535	0.317–0.904	0.019	0.563	0.321–0.987	0.045	0.405
rs1570360	1.087	0.741–1.595	0.670	1.021	0.676–1.542	0.922	1.000
rs2010963	0.683	0.463–1.008	0.055	0.622	0.407–0.953	0.029	0.261
rs3025039	1.359	0.870–2.123	0.178	1.571	0.980–2.520	0.061	0.549
rs9582036	0.721	0.362–1.434	0.351	0.658	0.314–1.380	0.268	1.000
rs9554320	1.107	0.672–1.823	0.690	1.026	0.596–1.768	0.926	1.000
rs1870377	0.929	0.626–1.378	0.714	0.893	0.575–1.386	0.613	1.000
rs307821	0.722	0.438–1.190	0.201	0.808	0.468–1.393	0.442	1.000
rs307826	0.645	0.382–1.088	0.100	0.708	0.398–1.260	0.241	1.000

WT is reference

Significant associations (p value < 0.05) are highlighted in bold

^aUnadj.—unadjusted p value

^bAdj.—p values were adjusted by using Bonferroni method

^cBivariable Cox regression models included always TNM stage and the specified SNP