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. 2003 Dec 16;74(1):128–138. doi: 10.1086/381055

Figure 3.

Figure 3

Unrooted phylogenetic tree of several members of the diacylglycerol, sphingosine, and ceramide kinases, including the human and murine CERKL sequences described in the present study (boxed). The tree was obtained with the neighbor-joining algorithm of the program ClustalX version 1.64b. Numbers show the values for the bootstrap analysis. SPHKs = sphingosine kinases; CERKs = ceramide kinases; and DGKs = diacylglycerol kinases. Abbreviations and GenBank accession numbers are as follows: human sphingosine kinase 1 (hSPHK1), AAF73423; murine sphingosine kinase 1 (mSPHK1), AAC61697; human sphingosine kinase 2 (hSPHK2), AAF74124; murine sphingosine kinase 2 (mSPHK2), AAF74125; Drosophila sphingosine kinase (dSPHK), AAF48045; Ciona intestinalis sphingosine kinase (ciSPHK), AK112588; yeast sphingosine kinase Lcb4 (Lcb4p), NP_014814; yeast sphingosine kinase Lcb5 (Lcb5p), NP_013361; Arabidopsis thaliana sphingosine kinase (AtSPHK), AY128394; human ceramide kinase (hCERK), AB079066; murine ceramide kinase (mCERK), AB079067; Ciona intestinalis ceramide kinase (ciCERK), AK112750; Drosophila ceramide kinase (dCERK), AAF52040; human ceramide kinase-like (hCERKL), AY357073; murine ceramide kinase-like (mCERKL), BY742285 and BC046474; Caenorhabditis elegans ceramide kinase (cCERK), AAC67466; human diacylglycerol kinase β subunit (hDGKb), Q9Y6T7; murine diacylglycerol kinase β subunit (mDGKb), XP_147651; human diacylglycerol kinase epsilon subunit (hDGKe), NP_003638; murine diacylglycerol kinase epsilon subunit (mDGKe), NP_062378); Caenorhabditis elegans diacylglycerol kinase 1 (cDGK1), NP_508190; Arabidopsis thaliana diacylglycerol kinase 1 (AtDGK1), Q39017; Drosophila diacylglycerol kinase 2 (dDGK2), Q09103; and Drosophila diacylglycerol kinase 1 (dDGK1), Q01583.