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. 2003 Nov 21;74(1):180–187. doi: 10.1086/381132

Figure 4.

Figure 4

Schematic representation of putative genomic rearrangements in the amplicon structure of the AZFc sequence, in men from Y haplogroup R (GenBank reference sequence), that could lead to an AZFc amplicon structure with u3 adjacent to the P1.2-g2-DAZ3-DAZ4-g3 AZFc segment. After the proposed inversion, mediated by b2/b3, the g1 and g3 amplicons flank the contiguous u3-P1.2-g2-DAZ4-DAZ3 AZFc segment with direct polarity. Recombination between the g1/g3 amplicons in this proposed pre-N AZFc sequence would then lead to deletion of an AZFc segment in men with Y haplogroup N as indicated. This AZFc structure is different from that proposed by Repping et al. (2003) for structures with gr/gr deletions found in 14 different Y haplogroups but not in N (illustrated above the GenBank reference sequence). Recombinations of gr/gr deletions can take place between g1/g2 amplicons, r1/r3 amplicons, and r2/r4 amplicons, respectively, as indicated by the three brownish lines, but not between the g1/g3 amplicons, as found in men from Y haplogroup N. For further details, see text.