Table 2.
Haplotype Frequencies by Group[Note]
|
Frequency in AJ Group |
Frequency in SOJ Group |
||||||||
| CD Familialb |
|||||||||
| Haplotype | Control(n=492) | MultiplexUnaffecteda(n=52) | CD Sporadic(n=72) | Total(n=143) | Central Europe(n=50) | Eastern Europe(n=67) | Control(n=164) | MultiplexUnaffecteda(n=8) | CDFamilialb(n=32) |
| A | .705 | .712 | .694 | .559 | .420 | .597 | .709 | 1.0 | .563 |
| B | .012 | .000 | .056 | .028 | .040 | .030 | .018 | .000 | .094 |
| C | .016 | .019 | .014 | .028 | .000 | .045 | .000 | .000 | .000 |
| B+C (702W) | .028 | .019 | .069 | .056 | .040 | .075 | .018 | .000 | .094 |
| D (908R) | .043 | .038 | .083 | .112 | .200c | .075 | .036 | .000 | .188 |
| E | .014 | .019 | .000 | .077 | .105 | .060 | .000 | .000 | .063 |
| F | .016 | .038 | .056 | .056 | .107 | .030 | .000 | .000 | .000 |
| E+F (1007fs) | .030 | .058 | .056 | .133 | .200 | .090 | .000 | .000 | .063 |
| I (852S) | .012 | .019 | .014 | .035 | .040 | .045 | .018 | .000 | .000 |
| G | .075 | .038 | .069 | .063 | .040 | .090 | .110 | .000 | .063 |
| H | .106 | .115 | .014 | .042 | .060 | .030 | .110 | .000 | .031 |
| Common mutationsc | .101 | .115 | .208 | .301 | .440d | .240 | .054 | .000 | .345 |
Note.— n = number of chromosomes.
a
Independent chromosomes carried by no affected individual in family.
b
Independent chromosomes carried by at least one affected individual in family.
c
702W, 908R, and 1007fs.
d
Significant (P<.05) difference between Central Europe and Eastern Europe.