Table 3.
ORs and χ2 Values for Sporadic Cases (by Case-Control Analysis) and Multiplex Sibships (by TDT Analysis) and Mantel-Haenszel Combined Estimates[Note]
|
AJ Sporadic |
Multiplex |
CombinedMantel-Haenszel |
||||||||||
| AJ |
SOJ |
Total |
||||||||||
| Haplotype | OR (95% CI) | χ2 | T/NT | OR | χ2 | T/NT | OR | χ2 | OR (95% CI) | χ2 | OR (95% CI) | χ2 |
| B | 5.19 (1.61–16.2) | 7.63** | 1/1 | 1.00 | .00 | 5/0 | ∞ | 5.00* | 6.00 (.94–38.5) | 3.57* | 5.40 (1.8–16.3) | 8.95** |
| C | .97 (.53–1.8) | .00 | 3/2 | 1.50 | .20 | 0/0 | … | … | 1.50 (.25–8.9) | .20 | 1.25 (.31–5.0) | .10 |
| B+C (702W) | 2.78 (1.0–7.7) | 3.88* | 4/3 | 1.33 | .14 | 5/0 | ∞ | 5.00* | 3.00 (.87–10.4) | 3.00* | 2.87 (1.3–6.5) | 6.30** |
| D (908R) | 2.22 (.88–5.6) | 2.86* | 18/5 | 3.60 | 7.35** | 7/6 | 1.17 | .08 | 2.27 (1.1–4.5) | 5.44* | 2.26 (1.3–4.0) | 7.88** |
| E | .00 | .90 | 11/3 | 3.67 | 4.57* | 5/0 | ∞ | 5.00* | 5.33 (1.8–16.0) | 8.89** | 3.71 (1.2–11.5) | 5.14* |
| F | 3.89 (1.2–12.3) | 5.38* | 10/4 | 2.50 | 2.57 | 0/0 | … | … | 2.50 (.82–7.7) | 2.57 | 3.08 (1.3–7.2) | 6.81** |
| E+F (1007fs) | 2.08 (.68–6.4) | 1.65 | 21/7 | 3.00 | 7.00* | 5/0 | ∞ | 5.00* | 3.71 (1.7–8.1) | 10.9*** | 3.03 (1.6–5.9) | 10.44** |
| I(852S) | 1.30 (.16–10.6) | .06 | 7/1 | 7.00 | 4.50* | 0/0 | … | … | 7.00 (1.2–42.3) | 4.50* | 3.06 (.69–13.7) | 2.15 |
| B+C+D+E+F+I | 2.22 (1.2–4.1) | 6.63** | 50/16 | 3.13 | 17.5*** | 17/6 | 2.83 | 5.26* | 3.05 (1.9–4.8) | 22.8*** | 2.71 (1.9–4.0) | 26.8*** |
| G | .94 (.40–2.2) | .02 | 8/13 | .62 | 1.19 | 2/3 | .67 | .20 | .63 (.29–1.4) | 1.38 | .73 (.39–1.4) | .98 |
| H | .13 (.05–.31) | 5.32* | 4/6 | .67 | .40 | 1/2 | .50 | .33 | .63 (.21–1.9) | .69 | .43 .16–1.2) | 2.83 |
Note.— For sporadic cases, OR and χ2 were derived from case-control analysis using haplotype A as reference for haplotypes G and H, and haplotypes A+G+H (grouped) as the reference for haplotypes B, C, D, E, and I. For multiplex cases, OR and χ2 were derived from TDT analysis. T/NT = number of transmitted/number of nontransmitted alleles from heterozygous parents; for transmission of haplotypes B, C, D, E, F, or I from heterozygous parents, the parent’s other haplotype could be A, G, or H; for transmission of haplotypes G or H from heterozygous parents, the parent’s other haplotype could only be A. Combined OR and χ2 based on Mantel-Haenszel analysis of sporadic (case-control) and both multiplex (TDT) values. P values for haplotypes B, C, D, E, F, and I are based on one-sided tests; P values for haplotypes G and H are based on two-sided tests. *P<.05; **P<.01; ***P<.001.