Table 2.
Adverse events (NCI-CTCAE v.4.0)
| Toxicity | Grade [n (%)] | |||
|---|---|---|---|---|
| 1 | 2 | 3 | 4 | |
| Early (n = 33) | ||||
| Mucositis | 0 | 7 (21) | 26 (79) | 0 |
| Dermatitis | 0 | 22 (67) | 11 (33) | 0 |
| Neutropenia | 1 (3) | 12 (36) | 16 (48) | 1 (3) |
| Anemia | 12 (36) | 13 (39) | 0 | 0 |
| Thrombocytopenia | 5 (15) | 3 (9) | 0 | 0 |
| Nausea | 15 (45) | 10 (30) | 6 (18) | – |
| Dry mouth | 12 (36) | 18 (54) | 3 (9) | – |
| Weight loss | 21 (64) | 10 (30) | 2 (6) | – |
| Hiccups | 4 (12) | 4 (12) | 1 (3) | 0 |
| Hepatobiliary disorders | 1 (3) | 0 | 0 | 0 |
| Fever | 3 (9) | 4 (12) | 0 | 0 |
| Depression | 1 (3) | 2 (6) | 0 | 0 |
| Catheter-related infection | – | 0 | 4 (12) | – |
| Edema (face, neck) | 24 (73) | 0 | 0 | |
| Late (n = 30) (2 years after treatment) | ||||
| Osteonecrosis of jaw | 0 | 1 (3) | 0 | 0 |
| Dysgeusia | 11 (37) | 5 (17) | – | – |
| Xerostomia | 17 (57) | 1 (3) | 0 | – |
| Dental caries | 0 | 10 (33) | 4 (13) | – |
National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0