Table 1.

Association of SNPs with DSM-IV Alcohol Dependence and EEG^[Note]

Markera	Gene	Function	Numberb	Positionc	AlcoholDependenceP Valued	EEG-βP Valuee
rs1497570	GABRG1	IVS8		45896957	.65	.68
rs1948609	GABRG1	IVS5		45912695	.88	.86
rs1391175	GABRG1	IVS1		45951087	.050*	.41
rs2221020	GABRG1	IVS1		45953488	.068	.98
rs1391168	GABRG1	IVS1		45965082	.45	.85
rs904154	GABRG1	5′	1	45976294	.19	.18
rs490434	GABRA2	3′	2	46043202	.0052*	.64
rs576666	GABRA2	3′	3	46052300	.095	.067
rs531460	GABRA2	3′	4	46060193	.022*	.024*
rs561779	GABRA2	3′	5	46088701	.048*	.044*
rs495818	GABRA2	3′	6	46097821	.022*	.034*
rs497068	GABRA2	3′		46100600	.0069*	.26
rs572227	GABRA2	3′		46101316	.038*	.019*
rs573400	GABRA2	3′UTR		46101989	.062	.27
rs541418	GABRA2	IVS9		46103139	.020*	.10
rs481311	GABRA2	IVS9		46104305	.076	.17
rs507788	GABRA2	IVS9	7	46107381	.031*	.068*
rs532780	GABRA2	IVS9		46111289	.079	.016*
rs548583	GABRA2	IVS9		46113267	.012*	.028*
ss15649713	GABRA2	IVS9		46113787	.103	.56
rs496650	GABRA2	IVS8	8	46114308	.054	.75
rs540363	GABRA2	IVS8	9	46124169	.044*	.49
rs526752	GABRA2	IVS8		46126552	.12	.07
rs530329	GABRA2	IVS8		46131042	.034*	.048*
rs483160	GABRA2	IVS8	10	46136998	.15	.036*
rs279871f	GABRA2	IVS7	11	46155656	.0004*	.049*
rs279867	GABRA2	IVS6		46158226	.24	.05*
rs279866	GABRA2	IVS6		46159687	.029*	.037*
rs279863	GABRA2	IVS5		46162945	.017*	.011*
rs279861	GABRA2	IVS5		46163248	.037*	.045*
rs279858	GABRA2	Exon 5	12	46164516	.0087*	.22
rs175931	GABRA2	IVS4		46166246	.10	.071*
rs279843	GABRA2	IVS4	13	46175127	.049*	.30
rs279845f	GABRA2	IVS4	14	46179646	.013*	.011*
rs279846	GABRA2	IVS4		46179809	.017*	.012*
rs183961	GABRA2	IVS4		46180951	.038*	.014*
rs1440130	GABRA2	IVS4		46183176	.013*	.017*
rs279826	GABRA2	IVS4	15	46184132	.0008*	.25
ss15649712	GABRA2	IVS4		46184417	.014*	.70
rs279827	GABRA2	IVS3		46184625	.0068*	.016*
rs279828	GABRA2	IVS3		46184733	.0086*	.02*
rs279834	GABRA2	IVS3		46188222	.015*	.027*
rs279836f	GABRA2	IVS3	16	46188993	.0071*	.0066*
rs279837	GABRA2	IVS3		46189246	.035*	.064
rs279841	GABRA2	IVS3		46190686	.038*	.018*
rs189957	GABRA2	IVS3	17	46196602	.053*	.27
rs1442059	GABRA2	IVS3	18	46206875	.034*	.018*
rs1442061	GABRA2	IVS3		46221143	.37	.24
rs1442062	GABRA2	IVS3	19	46226999	.22	.13
ss15649711	GABRA2	IVS3	20	46237967	.76	.57
ss15649710	GABRA2	IVS 1		46240788	.91	.97
rs3756007	GABRA2	IVS 1		46240987	.99	.98
rs894269	GABRA2	5′	21	46243535	.097	.84
rs2165607	GABRA2	5′		46250144	.44	.67
rs1545234	GABRA2	5′	22	46254336	.41	.62
rs2036943	Intergenic	5′	23	46726482	.85	.030*
rs2055943	GABRA4	IVS7		46817202	.72	.70
rs1512135	GABRA4	IVS6		46823811	.63	.38
rs1877400	GABRA4	IVS5		46827224	.90	1.00
rs2280072	GABRA4	IVS1		46845093	.53	.79
rs2280071	GABRA4	5′UTR		46845289	.98	.96
rs2055940	GABRA4	5′UTR		46847836	.36	.29
rs2119780	GABRB1	IVS4		47014133	.33	1.00
rs989808	GABRB1	IVS4		47016704	.77	.50
rs1372496	GABRB1	IVS4		47057731	.99	.53
rs1372497	GABRB1	IVS4		47072261	.53	.81
rs6284	GABRB1	IVS5		47172142	.98	.54
rs2070922	GABRB1	IVS7		47255971	.22	.61
rs6289	GABRB1	IVS8		47258632	.63	.66

Note.— Significant P values are indicated with an asterisk (*).

^aMarkers are shown as rs numbers (or ss numbers, for those we submitted that are not yet included) from the dbSNP database.

^bRefers to the numbering in figure 2.

^cPosition is in nucleotides from chromosome 4pter, as estimated in the dbSNP database (build 116) or by blasting against the NCBI Human Genome assembly (build 33).

^dP value for alcohol dependence, based on the average PDT (Martin et al. 2000).

^eP value for EEG-β, based on a measured genotype test (Boerwinkle et al. 1986) implemented in SOLAR (Almasy and Blangero 1998).

^fMarker used for the haplotype analysis in table 2.