Table 2.

Association of Haplotypes with Alcohol Dependence

			Parental Contribution		No. of Discordant Sibs
Haplotypea	Frequency	% of AllHaplotypes	No. ofTransmittedAlleles	No. ofNontransmittedAlleles	Affected	Unaffected	P Valueb
1	287	5.5	76	69	67	61	.66
2	226	4.3	57	61	44	39	.94
3	74	1.4	11	19	8	17	.25
4	2,531	48.5	728	589	549	518	.000000022
5	1,724	33.1	454	437	354	395	.67
6	68	1.3	8	15	8	11	.70
7	54	1.0	9	17	3	5	.96
8	252	4.8	59	77	47	60	.17

^aHaplotype derived from three markers (see footnote “f” in table 1); the high-risk haplotype (4) is rs279871 (A), rs279845 (T), rs279836 (A).

^bP values are based on the average PDT (Martin et al. 2000), treating each haplotype as a marker in an eight-allele system.