Table 3.

Association between Consecutive Three-SNP Haplotypes in GABRA2 and Alcohol Dependence^[Note]

Marker	OverallSignificancea	Significance ofHigh-RiskHaplotypeb
rs490434	…	…
rs576666	…	…
rs531460	.0066	.000034
rs561779	.0030	.000075
rs495818	.0064	.000077
rs497068	.0075	.00010
rs572227	.0037	.000035
rs573400	.0113	.00050
rs541418	.0088	.0011
rs481311	.0164	.00010
rs507788	.0127	.00020
rs532780	.0428	.00070
rs548583	.0028	.000039
ss15649713	.0258	.00050
rs496650	.0187	.0010
rs540363	.0427	.0010
rs526752	.0156	.00020
rs530329	.0060	.00020
rs483160	.0071	.000084
rs279871	.00010	.000003
rs279867	.000000	.000001
rs279866	.000003	.000001
rs279863	.00090	.000004
rs279861	.0052	.000050
rs279858	.0086	.00030
rs175931	.0030	.00010
rs279843	.0082	.000096
rs279845	.00080	.000013
rs279846	.0340	.0014
rs183961	.0042	.000051
rs1440130	.0018	.000015
rs279826	.0042	.000061
ss15649712	.0318	.0062
rs279827	.0240	.0068
rs279828	.0114	.0029
rs279834	.0141	.000041
rs279836	.0011	.000004
rs279837	.0025	.000019
rs279841	.0019	.000023
rs189957	.00080	.000027
rs1442059	.031	.00020
rs1442061	.022	.0030
rs1442062	.013	.00010
ss15649712	.026	.00040
ss15649710	.059	.0040
rs3756007	.35	.0275
rs894269	.15	.0026
rs2165607	.026	.0023
rs1545234	.24	.0865

Note.— Each set of three consecutive SNPs through the GABRA2 gene was analyzed as an eight-allele marker, named by the third SNP in the set.

^aP value based on the average PDT (Martin et al. 2000), treating each haplotype as a marker in an eight-allele system; the value is shown at the third of the three SNPs used to create each haplotype.

^bSignificance of the high-risk haplotype within each set of three consecutive SNPs.