Figure  3.

NPL analysis of 25 families with bipolar disorder from the Portuguese Island Collection. The number of each chromosome is shown at the top of each plot. The X-axis indicates the physical position (Mb) of the SNP marker. The Y-axis indicates the NPL Z score (black) or Kong and Cox LOD score (gray). For this scan, the empirical limit for genomewide significance was an NPL score of 3.85 and a LOD score of 3.15. Note that only the peak on chromosome 6 at 125.8 Mb was significant when both NPL Z and LOD thresholds were used.