Figure 2.

Comparison data for four euploid cffDNA AF samples, each hybridized separately with male and female reference DNA. Data show the expected ratio differences for clones from chromosomes X, Y, and 21, when sample genomes are compared with both a normal male genome and a normal female genome. Samples are labeled by sex and number, followed by the karyotype of the reference DNA used for hybridization. A subset of GenoSensor Array 300 (Vysis) clones, including markers on chromosomes 21, X, and Y, is shown for each array result. T/R = target DNA to reference euploid DNA ratio of fluorescent intensities (background corrected and normalized). Markers with increased copy numbers (>1.2) are highlighted in black, and markers with decreased copy numbers (<0.8) are highlighted in gray. Copy number changes with P values of <.01 are considered significant and are underlined and shown in bold.