Table 5.
TDT for Single Markers (GAS)[Note]
|
No. of Alleles |
|||||
| Sample andMarker | Known Gene | Allele | Transmitted | Not Transmitted | P |
| Yale families:a | |||||
| C_11488062_10b | … | G | 27 | 9 | .002 |
| rs3744161c | TBCD | G | 29 | 17 | .052 |
| Canadian families:d | |||||
| C_11488062_10b | … | G | 18 | 8 | .038 |
| rs662669c | TBCD | T | 23 | 12 | .045 |
| rs3744161c | TBCD | G | 23 | 11 | .029 |
| Toronto families: | |||||
| C_11600340_10b | SECTM1 | G | 76 | 49 | .0098 |
| rs1056534c | TBCD | C | 65 | 43 | .021 |
| rs662669c | TBCD | T | 65 | 44 | .027 |
Note.— Transmission of all 25 SNPs genotyped was tested. Only statistically significant results are presented here.
a
Analysis performed on the entire sample of large families available at the Yale site.
b
Applied Biosystems assay SNP ID.
c
dbSNP ID.
d
Analysis performed on the large Canadian families only.