Table 3.
True Type I Errors with Distortion of |
||||||
13:12, with TRD from |
6:5, with TRD from |
3:2, with TRD from |
||||
No. of AffectedSiblings and Sample Size | One Parent | Both Parents | One Parent | Both Parents | One Parent | Both Parents |
2: | ||||||
100 | .0103 | .0106 | .0117 | .0136 | .0204 | .0389 |
400 | .0106 | .0113 | .0136 | .0182 | .0390 | .116 |
1,600 | .0113 | .0127 | .0182 | .0315 | .116 | .475 |
6,400 | .0127 | .0160 | .0315 | .0820 | .475 | .986 |
3: | ||||||
100 | .0106 | .0113 | .0137 | .0183 | .0384 | .105 |
400 | .0112 | .0125 | .0176 | .0293 | .0971 | .367 |
1,600 | .0124 | .0153 | .0283 | .0678 | .362 | .931 |
6,400 | .0152 | .0224 | .0662 | .243 | .938 | 1.00 |
Note.— These results are for a nominal level of 1%, for nuclear families with two or three affected siblings and varying degrees of TRD.