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. 2004 Aug 20;75(4):571–586. doi: 10.1086/424528

Table 3.

True Type I Errors Associated with Spairs[Note]

True Type I Errors with Distortion of
13:12, with TRD from
6:5, with TRD from
3:2, with TRD from
No. of AffectedSiblings and Sample Size One Parent Both Parents One Parent Both Parents One Parent Both Parents
2:
 100 .0103 .0106 .0117 .0136 .0204 .0389
 400 .0106 .0113 .0136 .0182 .0390 .116
 1,600 .0113 .0127 .0182 .0315 .116 .475
 6,400 .0127 .0160 .0315 .0820 .475 .986
3:
 100 .0106 .0113 .0137 .0183 .0384 .105
 400 .0112 .0125 .0176 .0293 .0971 .367
 1,600 .0124 .0153 .0283 .0678 .362 .931
 6,400 .0152 .0224 .0662 .243 .938 1.00

Note.— These results are for a nominal level of 1%, for nuclear families with two or three affected siblings and varying degrees of TRD.