Table 5.
Results of Power Calculations Performed for Pedigrees[Note]
|
Value for Pedigree |
|||||||||
| B |
C or D |
E |
Fb |
||||||
| Model, Penetrances for Genotypes, KS (%),and Markera | Nad | Nad:Npairs | Nad | Nad:Npairs | Nad | Nad:Npairs | Nad | Nad:Npairs | Nad:N*pairs |
| Recessive (q = .316): | |||||||||
| DD = .08, Dd = .08, dd = .78, KS = 25.9: | |||||||||
| M1 | 238 | 1.9 | 111 | 1.08 | 102 | 1.04 | 65 | .63 | 1.03 |
| M2 | 373 | 1.97 | 168 | 1.08 | 156 | 1.05 | 94 | .6 | 1.07 |
| DD = .10, Dd = .10, dd = .60, KS = 20.5: | |||||||||
| M1 | 538 | 1.82 | 288 | 1.1 | 261 | 1.08 | 145 | .67 | 1.01 |
| M2 | 841 | 1.86 | 459 | 1.12 | 411 | 1.1 | 211 | .63 | 1.05 |
| DD = .12, Dd = .12, dd = .40, KS = 16.7: | |||||||||
| M1 | 3,582 | 1.93 | 1,862 | 1.13 | 2,067 | 1.11 | 1,020 | .73 | .95 |
| M2 | 5,364 | 1.97 | 2,746 | 1.17 | 2,955 | 1.1 | 1,365 | .68 | 1 |
| DD = .13, Dd = .13, dd = .33, KS = 15.9: | |||||||||
| M1 | 8,738 | 1.1 | 7,824 | 1.2 | 7,106 | 1.16 | 3,791 | .68 | .99 |
| M2 | 13,875 | 1.07 | 11,714 | 1.32 | 9,413 | 1.18 | 4,590 | .66 | 1 |
| Dominant (q = .0513): | |||||||||
| DD = .08, Dd = .78, dd = .78, KS = 29.5: | |||||||||
| M1 | 124 | .66 | 109 | .84 | 106 | .79 | 40 | .35 | 1.33 |
| M2 | 199 | .71 | 166 | .86 | 163 | .8 | 55 | .32 | 1.41 |
| DD = .10, Dd = .60, dd = .60, KS = 22.4: | |||||||||
| M1 | 371 | .9 | 260 | .92 | 255 | .86 | 91 | .35 | 1.34 |
| M2 | 591 | .98 | 389 | .94 | 372 | .87 | 125 | .32 | 1.4 |
| DD = .12, Dd = .40, dd = .40, KS = 17.3: | |||||||||
| M1 | 3,203 | 1.27 | 2,283 | .95 | 2,237 | 1.07 | 572 | .37 | 1.33 |
| M2 | 5,250 | 1.44 | 3,340 | .95 | 3,113 | 1.07 | 773 | .3 | 1.42 |
| DD = .13, Dd = .33, dd = .33, KS = 16.2: | |||||||||
| M1 | 6,277 | .92 | 6,634 | 1.01 | 6,431 | .89 | 1,992 | .41 | 1.26 |
| M2 | 9,939 | .89 | 7,482 | .98 | 10,494 | .9 | 2,643 | .38 | 1.29 |
| Additive (q = .1): | |||||||||
| DD = .08, Dd = .43, dd = .78, KS = 22.4: | |||||||||
| M1 | 414 | 1.05 | 281 | .93 | 268 | .88 | 113 | .39 | 1.3 |
| M2 | 662 | 1.07 | 406 | .93 | 426 | .88 | 151 | .36 | 1.34 |
| DD = .10, Dd = .35, dd = .60, KS = 18.8: | |||||||||
| M1 | 1,286 | 1.08 | 872 | .95 | 827 | .94 | 314 | .41 | 1.28 |
| M2 | 1,990 | 1.09 | 1,257 | .92 | 1,227 | .96 | 429 | .37 | 1.32 |
| DD = .12, Dd = .26, dd = .40, KS = 16.1: | |||||||||
| M1 | 9,079 | 1.19 | 5,626 | .98 | 6,100 | .81 | 2,136 | .5 | 1.18 |
| M2 | 12,193 | 1.08 | 9,176 | .92 | 10,731 | .9 | 2,971 | .47 | 1.21 |
| DD = .13, Dd = .23, dd = .33, KS = 15.6: | |||||||||
| M1 | 22,717 | 1.09 | 27,662 | 1.17 | 23,556 | 1.12 | 12,015 | .28 | 1.49 |
| M2 | 45,148 | 1.17 | 30,897 | 1.14 | 45,072 | 1.01 | 20,300 | .18 | 1.69 |
Note.— Pedigree labels refer to figure 1. All individuals are genotyped.
a
Penetrances are given in terms of the genotypes at the disease locus, where d is the susceptibility allele, with frequency q. KS is the sibling recurrence risk for the disease model. In all cases, the disease prevalence is 15%.
b
For pedigree F, N*pairs is related to the power of Spairs if the grandmother's status was affected instead of unknown.