Table 7.

Power of S_ad under the Effects of TRD^[Note]

	Power
Model, Penetrances for Genotypes, KS (%),and Markera	No TRD	3:2 (one)	3:2 (both)	3:1 (both)
Recessive (q = .316):
DD = .12, Dd = .12, dd = .40, KS = 16.7:
M1	.386	.381	.364	.258
M2	.272	.283	.267	.174
DD = .13, Dd = .13, dd = .33, KS = 15.9:
M1	.103	.105	.090	.071
M2	.073	.075	.068	.051
Dominant (q = .0513):
DD = .12, Dd = .40, dd = .40, KS = 17.3:
M1	.371	.363	.304	.218
M2	.276	.278	.253	.152
DD = .13, Dd = .33, dd = .33, KS = 16.2:
M1	.106	.095	.083	.046
M2	.085	.071	.063	.045
Additive (q = .1):
DD = .12, Dd = .26, dd = .40, KS = 16.1:
M1	.103	.097	.082	.045
M2	.066	.071	.066	.036
DD = .13, Dd = 2, dd = .33, KS = 15.6:
M1	.046	.024	.034	.011
M2	.035	.020	.027	.007

Note.— Power of S_ad under the effects of TRD, for sibships of varying sizes with a single unaffected sibling genotyped and without parental data. Distortions are in ratio 3:2 coming from a single parent, 3:2 coming from both parents, and 3:1 coming from both parents.

^aPenetrances are given in terms of the genotypes at the disease locus, where d is the susceptibility allele, with frequency q. K_S is the sibling recurrence risk for the disease model. In all cases, the disease prevalence is 15%.