Table 1.
P Values of the Difference in Breaks after Aphidicolin Treatment
|
P Values after Aphidicolin Treatment with |
|||||
| Breaks and LymphoblastCell Linea | .1 μM | .3 μM | .5 μM | .7 μM | .9 μM |
| Total: | |||||
| LB-5 vs. DK0060 | .09799 | .47319 | .34485 | .00630 | .03574 |
| LB-5 vs. DK0066 | .02672 | .00136 | 2.86×10-8 b | 4.37×10-5 b | 1.14×10-4 b |
| DK0060 vs. DK0066 | .21772 | .00124 | 2.32×10-8 b | 1.34×10-4 b | 2.91×10-4 b |
| At FRA3B: | |||||
| LB-5 vs. DK0060 | 1.0 | 1.0 | .1652 | .0513 | .5416 |
| LB-5 vs. DK0066 | .6212 | .0072 | 1.00×10-10 | 6.66×10-7 b | 1.67×10-4 b |
| DK0060 vs. DK0066 | .9999 | .0072 | 6.20×10-8 | .0045b | .0030b |
| At FRA16D: | |||||
| LB-5 vs. DK0060 | 1.0 | .3311 | 1.0 | .6133 | .8143 |
| LB-5 vs. DK0066 | .6212 | .0165 | 2.17×10-6 | 5.09×10-5 b | .0017b |
| DK0060 vs. DK0066 | .6212 | .1676 | 2.17×10-6 | 7.70×10-4 b | .0071b |
a
LB-5=normal; DK0060=heterozygote; DK0066=affected.
b
Of DK0066 metaphases analyzed, 16%–38% had a “shattered” appearance and were not included in these calculations; thus, the significance reported is an underestimate.