Figure 5.

Repeat instability in LBCL. Only expanded alleles are shown, to highlight the instability. A, In patient 9, the 3,760 repeat-expansion in PBL contracted to 3,500 through the EBV transformation (P1). The expanded allele gradually increased in size to 3,760 again (P1–P5). Moreover, a 3,000-repeat allele appeared in P5 and gradually replaced the 3,760 repeats. B, Patient 6 showed repeat-size heterogeneity through the transformation. Following the passages, the broad band converted to a tight one of 740 repeats. In patient 8, the allele with 1,300 repeats was stable throughout the passages and the transformation. P1–P12 = passages 1–12.