Pathway of purine metabolism. 1, ADSL. 2a, AICAR-TF. 2b, IMP-CH. 3, Adenylosuccinate synthetase. 4, AMP deaminase. 5, 5′-nucleotidase. 6, Purine nucleoside phosphorylase. 7, Adenosine deaminase. 8, HGPRT. 9, APRT. 10, Adenosine kinase. 11, Xanthine oxidase.