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. 2004 Sep 22;75(5):771–789. doi: 10.1086/425281

Figure 9.

Figure  9

Distribution over replicate simulations of the most extreme value of the test statistic T1 in a 400-cM region with no disease loci. This type of simulated distribution can be used to quantify empirical genomewide significance for the most extreme signals observed in a data set.