Table 1.
Allele Frequencies and P Values for Six DTNBP1 SNP Markers[Note]
|
Patients with Schizophreniaor Schizoaffective Disorder |
Patients with Schizophrenia |
||||||||||
| Minor-Allele Frequency |
Minor-Allele Frequency |
||||||||||
| Subset and SNP ID (dbSNP Number) | Alleles(Major/Minor) | Controlsa | Casesb | Allele P | Trend P | OR | Controlsa | Casesc | Allele P | Trend P | OR |
| White: | |||||||||||
| P1583 (rs909706) | C/T | .342 | .346 | .8795 | .8801 | 1.02 | .342 | .349 | .8051 | .8046 | 1.03 |
| P1578 (rs1018381) | C/T | .073 | .121 |
.0026 |
.0037 |
1.76 | .073 | .113 |
.0194 |
.0213 |
1.62 |
| P1763 (rs2619522) | A/C | .156 | .207 |
.0169 |
.0195 |
1.41 | .156 | .213 |
.0146 |
.0161 |
1.47 |
| P1320 (rs760761) | C/T | .163 | .197 | .1194 | .1276 | 1.26 | .163 | .207 | .0649 | .0676 | 1.34 |
| P1765 (rs2691528) | G/A | .157 | .208 |
.0171 |
.0195 |
1.41 | .157 | .213 |
.0162 |
.0176 |
1.46 |
| P1325 (rs1011313) | C/T | .070 | .060 | .4733 | .4786 | .85 | .070 | .058 | .4380 | .4397 | .82 |
| Hispanic: | |||||||||||
| P1583 (rs909706) | C/T | .345 | .330 | .8491 | .8496 | .94 | .345 | .325 | .8073 | .8150 | .91 |
| P1578 (rs1018381) | C/T | .060 | .177 | .0506 |
.0449 |
3.36 | .060 | .171 | .0654 |
.0460 |
3.23 |
| P1763 (rs2619522) | A/C | .154 | .324 |
.0243 |
.0319 |
2.63 | .154 | .305 |
.0480 |
.0565 | 2.41 |
| P1320 (rs760761) | C/T | .150 | .300 |
.0351 |
.0540 |
2.43 | .150 | .278 | .0775 | .1012 | 2.18 |
| P1765 (rs2691528) | G/A | .150 | .320 |
.0171 |
.0239 |
2.67 | .150 | .300 |
.0385 |
.0473 |
2.43 |
| P1325 (rs1011313) | C/T | .117 | .080 | .4411 | .4802 | .66 | .117 | .088 | .5692 | .6043 | .73 |
| African American: | |||||||||||
| P1583 (rs909706) | C/T | .221 | .234 | .7518 | .7567 | 1.08 | .221 | .236 | .72692 | .73135 | 1.09 |
| P1578 (rs1018381) | C/T | .317 | .301 | .7210 | .7270 | .93 | .317 | .301 | .72910 | .73492 | .93 |
| P1763 (rs2619522) | A/C | .390 | .357 | .4949 | .5043 | .87 | .390 | .356 | .49307 | .50293 | .87 |
| P1320 (rs760761) | C/T | .345 | .349 | .9286 | .9324 | 1.02 | .345 | .358 | .78009 | .79132 | 1.06 |
| P1765 (rs2691528) | G/A | .371 | .358 | .7715 | .7737 | .94 | .371 | .358 | .78441 | .78663 | .95 |
| P1325 (rs1011313) | C/T | .043 | .058 | .4819 | .4842 | 1.38 | .043 | .057 | .51561 | .52014 | 1.36 |
Note.— Significant P values are shown in bold, underlined italics. P values that approach significance are shown in bold italics.
a
Sample sizes were as follows: white (n=467), Hispanic (n=32), African American (n=74).
b
Sample sizes were as follows: white (n=258), Hispanic (n=51), African American (n=215).
c
Sample sizes were as follows: white (n=196), Hispanic (n=41), African American (n=184).