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. 2004 Sep 13;75(5):899–905. doi: 10.1086/425342

Figure 2.

Figure 2

Gain-of-function effect of the KCNE2 R27C mutation. A–C, Representative whole-cell current traces. These were recorded from COS-7 cells transfected with KCNQ1 alone (A), cells cotransfected with KCNQ1 and KCNE2 (B), and cells cotransfected with KCNQ1 and KCNE2 R27C (C). D, Plot of current density versus voltage for cotransfection of KCNQ1 and KCNE2 (▴) (n = 30) or for cotransfection of KCNQ1 and KCNE2 R27C (▪) (n=26) at room temperature. E, Comparison of current density at −110 mV (inward current) and +30 mV (outward current) at room temperature. Q1-T8A represents cells cotransfected with KCNQ1 and KCNE2 T8A (n=15); Q1-Q9E, cells cotransfected with KCNQ1 and KCNE2 Q9E (n=14); Q1-E2, cells cotransfected with KCNQ1 and KCNE2 (n=30); and Q1-R27C, cells cotransfected with KCNQ1 and KCNE2 R27C (n=26). Cells were held at −80 mV before depolarization to various test potentials from −120 mV to +60 mV in 10-mV increments for 2,000 ms and then were held at −40 mV for 500 ms.