Table 2.

The effect of cisplatin (CDDP) alone or in combination with quercetin or TAK779 on body weight, food intake and total muscle weight in BALB/c mice.

Treatment	Control	CDDP	CDDP+TAK779	CDDP+OQ	CDDP+IQ
Body weight before CDDP injection (g)	23.1 ± 1.1	22.3 ± 1.1	22.2 ± 0.9	22.0 ± 1.4	22.5 ± 1.0
Body weight at the end of the experiment (g)	30.3 ± 1.6	17.6 ± 1.2***	18.5 ± 1.9	17.9 ± 1.2	18.0 ± 1.8
Food intake (g/day)	7.4 ± 1.0	5.8 ± 0.7***	6.6 ± 1.8	5.9 ± 0.8	6.2 ± 0.8
Total muscle weight (g)	1,077 ± 66	527 ± 61***	638 ± 67##	590 ± 82	633 ± 68##

Quercetin was administered by a diet containing 1% quercetin (OQ) or intraperitoneal injection (IQ). The control group received the control diet and vehicle only. Values are expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 denote a significant difference from the control group; #p < 0.05, ##p < 0.01, ###p < 0.001 denote a significant difference from the CDDP group. Total muscle weight: the sum of tricepsquadriceps, quadriceps, and gastrocnemius muscle.