TABLE 1.
MHC class I ELA-A haplotypes and class II DRA and DQA alleles of experimental horses
| Horse | Age (mo)a | Group | ELA-A typeb | DRA type | DQA type | Dam |
|---|---|---|---|---|---|---|
| H637 | 17 | EIAV | A1/W11 | 1/1 | 5/12 | H504 |
| H640 | 6 | EIAV | A1′/A6′ | 1/1 | 4/11 | H607 |
| H641 | 6 | EIAV | A1′/NDc | 1/1 | 4/ND | H604 |
| H646 | 5 | EIAV | A1′/A5 | 1/1 | 4/ND | H615 |
| H651 | 4.5 | EIAV | A1′/A5 | 1/xd | 4 | H563 |
| H643 | 5.5 | Control | A1′/A5 | 1/1 | 4/ND | H606 |
| H648 | 5 | Control | A1′/A5 | 1/1 | 4/ND | H623 |
| H649 | 5 | Control | A1′/A5 | 1/x | 4 | H545 |
| H652 | 3.5 | Control | A1/W11 | 1/1 | 5/12 | H504 |
The age listed is the age at the first immunization.
Horses H637 and H652 shared the maternally derived ELA-A1/DRA*0101/DQA*1201 haplotype, whereas the remaining seven horses shared the paternally derived ELA-A1′/DRA*0101/DQA*0401 haplotype. Different designations were used because of apparent functional differences between ELA-A1 and ELA-A1′ described in the results.
ND, an allele was not detected by the available serological reagents (ELA-A) or available primer set (DQA), although pedigree information indicated that the individual was heterozygous.
The type x in DRA indicates a nonsequenced allele with a unique single-strand conformation polymorphism pattern.