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Pattern of immune reconstitution in the patient after PEG-ADA therapy starting at week 0 and changes because of the appearance of an IgG antibody to bovine ADA (arrow). The kinetics of total lymphocyte counts and lymphocyte subsets (CD4, CD8, and CD20 cells) (upper panel) and the course of naive and memory CD4 cells (CD4+/CD45RA+ and CD4+/CD45RO+) (lower panel) are shown.
