Table 2.

Summary of lethal and fitness mutations

Group	Stage	Defect onset	Mutation	Phenotype	Rw/+*× Rw/+*
					Rw	nonRw
Early	Pre/Peri-implantation	E3.5-E5.5	L5Jcs4		78	0
			L5Jcs7		92	0
			L5Jcs10		123	0
			L5Jcs14		104	1*
			L5Jcs22		60	0
			L5Jcs24		122	0
			L5Jcs25		72	0
			L5Jcs27		59	0
			L5Jcs30		82	0
			L5Jcs31		40	0
			L5Jcs35		33	0
	Post-implantation	E5.5-E7.5	L5Jcs6	Gastrulation	59	0
			L5Jcs8		95	0
			L5Jcs11	Gastrulation	64	0
			L5Jcs18	Gastrulation	82	1*
			L5Jcs36		29	0
			L5Jcs38	Gastrulation	63	0
	Undetermined	Pre E9.5-10.5	L5Jcs5		48	0
Middle	Midgestation	E8.5-E12.5	L5Jcs2		64	0
			L5Jcs3		97	0
			L5Jcs13		112	0
			L5Jcs15	CF/CV/placenta	120	0
			L5Jcs17	Growth retardation	55	0
			L5Jcs23	NTD	57	1
			L5Jcs28	Growth retardation	63	0
			L5Jcs32	NTD; pericardial edema	35	0
			L5Jcs33	CF/CV	32	2
			L5Jcs37	CF/CV/placenta	20	0
Late		E10.5-birth	L5Jcs20		38	0
			L5Jcs34		30	1
	Perinatal	E18.5-1dpp	L5Jcs1	Skeletal, bone defects	141	0
	Postnatal	1dpp-10dpp	L5Jcs16	Fitness, runty	69	0^
UNK			L5Jcs29		61	2
			L5Jcs26		33	0
			L5Jcs12		53	0
			L5Jcs19		73	0
				Total	2215	8

^(*)Sickly; (^) no runts at wean age; (CF) craniofacial; (CV) cardiovascular; (NTD) neural tube defects.