Table 3.

Disease Models and Estimated Power (%) for the Four Tests, at Significance Level α=1%, Using Weight Variables Defined on the Basis of Genotypes of One or Both Sibs^[Note]

	Estimated Power(%)
	Complete IBDInformation				Incomplete IBDInformation, Tmax
pD, f0/f1/f2, andNo. of Sibs	Tdom	Trec	Tadd	Tmax	d=2	d=5	d=10
.2:
.065/.162/.162:
1	85	3	72	79	71	62	49
2	95	4	86	92	86	78	65
.089/.089/.368:
1	72	100	98	100	99	98	95
2	83	100	100	100	100	100	98
.068/.148/.228:
1	80	32	83	81	74	64	51
2	92	45	93	91	86	78	66
.5:
.015/.128/.128:
1	27	1	4	19	15	11	9
2	55	1	5	45	40	32	24
.072/.072/.185:
1	28	92	86	88	84	76	63
2	40	98	94	96	93	89	78
.036/.100/.164:
1	44	51	68	64	55	46	36
2	66	68	83	83	76	67	54

Note.— Results are based on 10,000 replicates of 500 ASPs. p_D is the frequency of disease allele D in the population. f_i(i=0, 1, 2) is the penetrance for the genotype with i copies of allele D. Given incomplete IBD information, d (in cM) is the flanking marker density. All models have disease prevalence 10% and single-locus sib relative risk λ_S=1.1.