Figure  1.

The diverse clinical phenotypes of patients with OCA4. Both patients are 1-year-old Japanese girls. Patient 36, with D157N and V507L mutations, has blond hair and gray-blue irides (A). Patient 51, with D157N and S90CGGCCA→GC mutations, has light yellow hair and blue irides (B). Note the milder hypopigmentation of patient 36 compared with that of patient 51.