Table 2.
Comparison of Haplotype Frequency Estimated Using the S1, S2, and S3 Strategies for a Data Set Obtained Using the TaqMan Assay
|
Haplotype FrequencyEstimated using Strategyb |
||||
| Haplotypea | S1 | S2 | S3 | Benchmark Haplotype Frequency Estimatec |
| 0000 | .1378 | .1377 | .1347 | .116 |
| 0001 | .3905 | .3948 | .3917 | .408 |
| 0010 | .3591 | .3592 | .3637 | .357 |
| 0011 | .0044 | .0000 | .0000 | .000 |
| 0100 | .0557 | .0557 | .0574 | .051 |
| 1000 | .0513 | .0507 | .0505 | .061 |
| 1001 | .0001 | .0001 | .0001 | .003 |
| 1010 | .0012 | .0018 | .0019 | .000 |
a
Here, “0” stands for the major allele and “1” stands for the minor allele.
b
In this study, four SNP markers (from left to right: C26304T, C26602T, G28152A, and G36189A) in the XRCC1 gene were typed using the TaqMan assay for a subset of 315 individuals out of the overall sample (N=2,244).
c
The weighted average (case plus control) of haplotype frequency estimates reported by Han et al. (2003). The haplotype frequency estimates of the benchmark were obtained by using PLEM.