Table 2.

European and Canadian guidelines for OIT

Guidelines	Country	Key points/recommendations
EAACI guidelines [49]	Europe	• OIT is a therapeutic option for inducing desensitization in children from 4 to 5 years of age with an IgE-mediated food allergy for cow’s milk, eggs, and peanut • During the escalation phase, dose increases to be carried out under medical supervision within an infrastructure capable of treating allergic emergencies • Need for informed consent before the initiation of OIT • Contraindications and unresolved points identified
CSACI guidelines [2]	Canada	• Recommendations for a patient-centered practical approach, analyzing 22 criteria divided into 5 domains (sociopolitical, population, clinical, organizational, economic) • OIT can be offered to all patients, including adults, for all foods and also in the event of multiple food allergy • The notion of the severity of the initial reaction should not be taken into account to contraindicate OIT • Uncontrolled asthma is an absolute contraindication to starting OIT • During the escalation phase, dose increases to be carried out under medical supervision in a structure capable of treating allergic emergencies, with 1 h of monitoring • OIT can be carried out with various products, including those for industrial consumption • Need for informed consent before initiation of OIT

CSACI Canadian Society of Allergy and Clinical Immunology; EAACI European Academy of Allergy and Clinical Immunology (EAACI); OIT oral immunotherapy

Adapted from Pouessel G, Lezmi G. 2023 [48]