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. 2005 Aug 2;33(13):4368–4376. doi: 10.1093/nar/gki752

Figure 2.

Figure 2

Structure of the Toprim domain. Ribbon diagrams of the crystallographic structures of the Toprim domain of E.coli DnaG (PDB code 1DD9; residues 259–341), A.fulgidus reverse gyrase (1GKU; residues 504–524; 544–553; 607–659), E.coli Top1 (1CY0; residues 3–34; 90–141) and a model of the proposed Toprim domain of RNase M5 (residues 6–81). The positions of amino acids mutated in the Toprim domain of RNase M5 are indicated. The DxD motif is shown in red and the positions of the catalytic tyrosine residues of reverse gyrase and topoisomerase are also shown.