Figure 1.
(A) Schematic representation for the detection of the MIF CATT tetranucleotide repeat by ligation of biotinylated detection probe P2 to a set of capture probes P1 with different copies of CATT repeat immobilized on thin-film biosensor chip surface in the presence of certain CATT target (i.e. CATT 6). (B) Array template for the detection of the 5-, 6-, 7- and 8-CATT repeats, and the −173 G/C SNP. Oligonucleotides are arrayed in duplicates, as shown. +: positive control, an aldehyde modified dA20-biotin probe. (C) Visual appearance of the biochip arrays of the representative MIF genotypes.