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. 2005 Aug 1;19(15):1773–1778. doi: 10.1101/gad.1314605

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Copyright © 2005, Cold Spring Harbor Laboratory Press

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Figure 2. — Enhanced angiosarcomas and liver hemangiomas in Tsc2^+/- Pten^+/- mice. (a) Summary graph of the incidence of TSC-related tumors in Tsc2^+/- and Tsc2^+/- Pten^+/- mice. See text for details. (b) Macroscopic view of a typical angiosarcoma on the paw of a Tsc2^+/- Pten^+/- mouse at 40 wk. (c) A section from the tumor in b. (d) An angiosarcoma found adjacent to the spine of a Tsc2^+/- Pten^+/- mouse. (SkM) Skeletal muscle; (Sp) spine. The boxed region is shown at high magnification in the inset. (e) Kidney adenoma from a Tsc2^+/- Pten^+/- mouse at 6 mo. (f,g) Typical liver hemangioma from a 12-mo-old Tsc2^+/- mouse (f) compared with an example of the lesions found in Tsc2^+/- Pten^+/- mice (g). (c-g) H&E-stained tumors. (c-e) Arrowheads point to tumor borders. (h) Anti-TSC2 staining of a Tsc2^+/- Pten^+/- liver hemangioma and adjacent normal liver (NL). The staining within the vascular lesion is blood (bl). (i) High-magnification view of the box from h, demonstrating loss of TSC2 staining within the endothelial cells comprising the liver hemangioma. (j) Maintenance of PTEN expression in a Tsc2^+/- Pten^+/- liver hemangioma. Bars: b, 1 cm; c-g, 1 mm; d, inset, 100 μm; h, 200 μm; i,j, 40 μm.