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Experimental design
| Group | Number of pregnant sheep | Number of fetuses/lambs | Challenge (P.O.)a | Treatment (P.O.) |
|---|---|---|---|---|
| G1 | 8 | 15 | 10 TgShSp1 sporulated oocysts | BKI-1748, 10 doses at 15 mg/kg q.o.d.b, starting at 7 days post-infection |
| G2 | 8 | 16 | 10 TgShSp1 sporulated oocysts | None |
| G3 | 3 | 5 | PBS | 60% Phosal 53 MCT, 30% PEG400, 10% Ethanol 96°C (vehicle), 10 doses q.o.d. |
P.O.: per os, orally.
q.o.d.: every other day.
