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. 2015 Feb 26;141(8):1465–1474. doi: 10.1007/s00432-015-1937-y

Table 3.

Cox regression analyses of overall survival (OS) and BPTF, vimentin, E-cadherin expression levels as well as clinicopathological factors in patients with CRC

Variables Cases (n) Univariate analysis Multivariate analysis
HR (95 % CI) P HR (95 % CI) P
Age
 ≤60 64 1 1
 >60 41 1.073 (0.537–1.405) 0.496 1.113 (0.733–1.379) 0.594
Gender
 Male 65 1 1
 Female 40 0.733 (0.314–1.216) 0.638 0.905 (0.633–1.592) 0.273
Tumor size (cm)
 ≤5 62 1 1
 >5 43 1.529 (0.934–2.881) 0.093 1.414 (0.732–1.987) 0.154
Histology grade
 Low (G1–G2) 70 1 1
 High (G3–G4) 35 1.475 (0.588–2.243) 0.208 1.319 (0.772–1.846) 0.351
UICC stage
 I/II 61 1 1
 III/IV 44 2.933 (1.384–5.962) 0.001 2.285 (1.414–4.737) 0.008
Nodal metastasis
 Negative 61 1 1
 Positive 44 2.538 (1.227–4.913) 0.005 2.712 (1.334–5.216) 0.003
Recurrence
 Negative 68 1 1
 Positive 37 3.476 (1.932–6.062) 0.001 2.937 (0.971–5.136) 0.001
BPTF expression
 Low 34 1 1
 High 71 1.974 (0.812–3.285) 0.011 1.836 (0.692–3.735) 0.018
Vimentin expression
 Low 46 1 1
 High 59 2.038 (1.142–3.795) 0.010 1.573 (0.792–2.133) 0.084
E-cadherin expression
 High 27 1 1
 Low 78 1.916 1.155–4.038) 0.023 1.633 (0.583–2.977) 0.059

CI confidence interval, HR hazard ratio

Significant results (P < 0.05) are given in bold