Fig. 4.

Crystal packing of TLR3-ECD. Ribbon diagram of the TLR3-ECD symmetry-related dimer found in the crystal lattice. N-glycosylation is shown in green ball-and-stick, and the two sulfate ions are shown in yellow and red space-filling (S1 and S2). The side view (A) shows the predominance of glycan decorating the faces of the molecule. Looking down the crystallographic twofold between the molecules (B), a surface near the C terminus that is devoid of glycan allows for close contact between molecules. The interface contains four hydrogen bonds, one of which (Asp-575) is contributed by the insertion in LRR20 (shown in orange).