FIG. 2.
Dose-dependent inhibition of RSV replication by poly-ICLC. Groups of BALB/c mice were treated intranasally with increasing doses of poly-ICLC and 24 h later were infected with RSV (107 PFU/mouse). (A) Lung viral titer: 5 days after infection lung tissue was removed, and the viral titer was determined by a methylcellulose plaque assay. (B) Virus yield for each dose of poly-ICLC used is expressed as a percentage of the control and calculated as [(virus titer with poly-ICLC)/(virus titer without poly-ICLC)] × 100. The bar graph represents mean ± standard error of the mean (n = 3 to 12 mice/group). **, P < 0.01 compared with poly-ICLC-treated mice (at each dose).