FIG. 5.

Viral replication and lung inflammation are reduced in mice treated with IFN-α following RSV inoculation. BALB/c mice were infected with RSV and 3 days later were treated intranasally with 10⁴ IU of rIFN-α. (A) Two days after IFN-α treatment (i.e., 5 days after viral inoculation), lung tissue was removed and lung viral titer was determined. (B) Pathology score was determined at day 7 after RSV infection. Bar graphs represent mean ± standard error of the mean (n = 3 mice/group). *, P < 0.05 compared with untreated infected mice.