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HIV envelope-specific cellular immune responses. (A to D) Secretion of IFN-γ in response to overlapping HIVMN Env peptides. The results for individual chimpanzees are grouped by immunization dose. Arrows mark Ad5 and Ad7 recombinant immunizations at weeks 0 and 13 and HIVSF162 gp140ΔV2 boosts at weeks 37 and 49. (E) Proliferative responses to HIVIIIB gp120 prior to and 2 weeks after each HIVSF162 gp140ΔV2 boost. Mean SI ± the standard errors of the mean are shown.
