Table 2.

Thermodynamic parameters derived from ITC experiments measured for TBA quadruplex folding in 10 mM Cs–HEPES, pH 7.5 at 20°C

Molecule/complex	n	ΔG (kcal/mol)	ΔH (kcal/mol)	TΔS(kcal/mol)
K-TBA	3.1 ± 0.5	−5.5 ± 0.1	−21.6 ± 0.6	−16.1
K-TBA•1NC	3.2 ± 1.3	−4.5 ± 0.1	−6.4 ± 1.5	−1.9
Sr-TBA	1.0 ± 0.1	−8.5 ± 0.1	−14.3 ± 0.3	−5.8
Sr-TBA•1NC	1.2 ± 0.3	−7.4 ± 0.1	−5.3 ± 0.3	2.1