Table 3.
Cox proportional hazard model for overall survival in all patients
| Single Cox regression | Multiple Cox regression | |||||
|---|---|---|---|---|---|---|
| Variables | HR | 95% CI | P value | HR | 95% CI | P value |
| BMI<25(base) kg/m2 | - | - | - | - | - | - |
| 25<BMI<30 | 0.89 | 0.66 – 1.19 | 0.42 | 2.89 | 1.19- 7.07 | 0.02 |
| BMI>=30 | 1.15 | 0.85-1.55 | 0.36 | 2.97 | 1.19-7.42 | 0.02 |
| Tumor Type (base= Invasive ductal carcinoma) | ||||||
| Invasive lobular | 0.35 | 0.5-2.53 | 0.3 | |||
| Medullary | - | - | 0.96 | |||
| Mucinous | - | - | 0.97 | |||
| Papillary | - | - | 0.98 | |||
| TNM Stage(base= Stage1) | ||||||
| Stage2 | 1.63 | 0.8 -3.23 | 0.17 | |||
| Stage 3 | 2.74 | 1.14 – 6.59 | 0.02 | |||
| Permanent Pathology Tumor grade (base= Grade1) | ||||||
| Grade 2 | 1.81 | 0.81-4.04 | 0.15 | 1.17 | 0.48-2.88 | 0.73 |
| Grade 3 | 3.71 | 1.62-8.47 | 0.002 | 2.26 | 0.88-5.81 | 0.09 |
| Age at diagnosis | 1.02 | 0.99-1.03 | 0.1 | 1.02 | 0.99- 1.04 | 0.09 |
| Menopause status(base=Premenopause) | ||||||
| Postmenopausal | 1.27 | 0.6- 2.69 | 0.54 | |||
| Not identified | 0.74 | 0.47-1.19 | 0.21 | |||
| Surgery Type (base= Quadrantectomy (BCS)) | ||||||
| Mastectomy | 1.59 | 0.98-2.59 | 0.06 | 1.19 | 0.61- 2.32 | 0.62 |
| Quadrantectomy (BCS) , Mastectomy | 6.11 | 3.41-10.93 | <0.001 | 2.87 | 1.43 -5.78 | 0.003 |
| Tumor size (base = Tumor size <2 cm) | ||||||
| 2-5 cm | 1.64 | 0.94-2.87 | 0.08 | |||
| 5 cm< | 1.79 | 0.70-4.59 | 0.22 | |||
| Invasion (base= none) | ||||||
| Vascular | 1.34 | 0.79-2.28 | 0.27 | |||
| Preneural | 0.36 | 0.09-1.52 | 0.17 | |||
| Both of them | 1.81 | 1.06-3.09 | 0.03 | |||
| Lymphatic, Vascular | 0.96 | 0.13-7.02 | 0.96 | |||
| Margin | 0.76 | 0.19-3.11 | 0.71 | |||
| Axillary Type (base = AND) | ||||||
| SLNB | 0.33 | 0.18 - 0.62 | 0.001 | 0.36 | 0.10-1.23 | 0.10 |
| SLNB then ALND | 1.56 | 0.95 - 12.56 | 0.07 | 1.87 | 1.03- 3.40 | 0.04 |
| Hormone receptor (base= Luminal A) | ||||||
| Luminal B | 0.78 | 0.39- 1.55 | 0.48 | |||
| Her 2 | 2.02 | 1.10- 3.70 | 0.02 | |||
| Triple Negative | 1.83 | 1.03- 3.25 | 0.04 | |||
| Estrogen Receptor + | 2.01 | 1.29- 3.14 | 0.002 | |||
| Proegstrone Receptor + | 2.10 | 1.36 - 3.25 | 0.001 | |||
| Hormone receptor | 1.06 | 0.66 - 1.71 | 0.80 | |||
| Preoperative Chemotherapy | 1.95 | 1.20-3.15 | 0.01 | |||
| Postoperative Chemotherapy | 0.71 | 0.39 - 1.29 | 0.26 | |||
| Axillary and Chest Radiotherapy | 1.07 | 0.63-1.83 | 0.80 | |||
| Intraoperative radiation | 0.05 | 0.001- 3.48 | 0.20 | |||
| Hormone therapy | 0.54 | 0.35-0.85 | 0.01 | |||