Table 4.
Cox proportional hazard model for disease free survival in all patients
| Single Cox regression | Multiple regressiona | |||||
|---|---|---|---|---|---|---|
| Variables | HR | 95% CI | P value | HR | 95% CI | P value |
| BMI<25 (base) | - | - | - | |||
| 25<BMI<30 | 0.94 | 0.77-1.16 | 0.59 | |||
| BMI>=30 | 1.02 | 0.81-1.27 | 0.87 | |||
| Tumor type (base= Invasive ductal carcinoma) | ||||||
| Invasive lobular | 1.23 | 0.8 -1.91 | 0.35 | |||
| Medullary | 0.55 | 0.26 – 1.16 | 0.12 | |||
| Mucinous | 0.16 | 0.02 – 1.54 | 0.07 | |||
| Papillary | 0.42 | 0.06 – 2.97 | 0.38 | |||
| TNM Stage(base=stage 1) | ||||||
| Stage2 | 1.21 | 0.93 – 1.58 | 0.15 | 0.40 | 0.28-0.58 | <0.001 |
| Stage 3 | 3.14 | 2.30 – 4.30 | <0.001 | 0.55 | 0.41-0.73 | <0.001 |
| Permanent Pathology Tumor(Grade 1) | ||||||
| Grade 2 | 1.40 | 1.07 – 1.85 | 0.01 | |||
| Grade 3 | 1.80 | 1.33 – 2.44 | <0.001 | |||
| Age at diagnosis | 0.99 | 0.982- 0.998 | 0.01 | 0.99 | 0.98 -1.00 | 0.08 |
| Menopausal status (base = Premenopouse) | ||||||
| Postmenopausal | 1.62 | 1.19 -2.18 | 0.002 | |||
| Not identified | 1.2 | 1.00-1.44 | 0.04 | |||
| Surgery Type (base= Quadrantectomy (BCS)) | ||||||
| Mastectomy | 2.17 | 1.8-2.61 | <0.001 | 0.31 | 0.22- 0.45 | <0.001 |
| Quadrantectomy (BCS) | 4.26 | 3.24 -5.60 | <0.001 | 0.47 | 0.33- 0.68 | <0.001 |
| Tumor size(base <2 cm ) | ||||||
| 2-5 cm | 1.34 | 1.08-1.66 | 0.007 | |||
| 5 cm < | 1.82 | 1.28-2.60 | 0.001 | |||
| Permanent Pathology Tumor (base = Grade1) | ||||||
| Grade 2 | 1.4 | 1.07-1.85 | 0.01 | |||
| Grade 3 | 1.8 | 1.33 - 2.44 | <0.001 | |||
| margin | 1.30 | 0.85-1.99 | 0.23 | |||
| Axillary Type (base = AND) | ||||||
| SLNB | 0.32 | 0.26-0.40 | <0.001 | 1.35 | 1.02-1.78 | 0.03 |
| SLNB then ALND | 0.68 | 0.54-0.87 | 0.002 | 0.49 | 0.32- 0.75 | 0.001 |
| Hormone receptor (base= Luminal A) | ||||||
| Luminal B | 1.01 | 0.79-1.28 | 0.94 | 0.86 | 0.63-1.18 | 0.35 |
| Her2 | 1.49 | 1.15-1.93 | 0.003 | 1.37 | 0.97-1.92 | 0.07 |
| Triple Negative | 1.21 | 0.94-1.57 | 0.14 | 1.40 | 0.98-1.99 | 0.06 |
| Estrogen Receptor + | 1.32 | 1.09-1.60 | 0.004 | |||
| Progesterone Receptor + | 1.26 | 1.05-1.51 | 0.01 | |||
| Hormone receptor + | 1.13 | 0.94-1.36 | 0.18 | |||
| Preoperative chemotherapy | 2.4 | 1.98- 2.87 | <0.001 | |||
| Postoperative Chemotherapy | 0.58 | 0.47-0.72 | <0.001 | 1.74 | 1.24-2.44 | 0.001 |
| Postoperative Radiotherapy | 1.06 | 0.86-1.31 | 0.57 | |||
| Intraoperative radiation | 0.58 | 0.35-0.95 | 0.03 | |||
| Hormone therapy | 0.81 | 0.67-0.98 | 0.02 | |||
| Invasion (base= none) | ||||||
| Vascular | 1.40 | 1.13-1.74 | 0.002 | 1.05 | 0.77- 1.42 | 0.76 |
| Preneural | 0.96 | 0.66-1.39 | 0.82 | 1.12 | 0.62- 2.02 | 0.70 |
| Both of them | 1.71 | 1.37-2.14 | <0.001 | 1.40 | 1.04-1.88 | 0.03 |
| Lymphatic Vascular | 2.55 | 1.59 – 4.09 | <0.001 | 2.01 | 1.15-3.52 | 0.01 |
aBackward Stepwise (Wald)