Table 2.
MMPs and TIMPs immunoreactivity values in primary tumors from patients without tumoral recurrences, from patients with local recurrences, from patients with distant metastasis and in local recurrences
| Factor | Primary tumors of patients without tumoral recurrence | Primary tumors of patients with tumoral recurrence | Primary tumors of patients with distant metastasis | Univariate p value* | Multivariate p value* | Local recurrences | |||
|---|---|---|---|---|---|---|---|---|---|
| N | Median (range) | N | Median (range) | N | Median (range) | Median (range) | |||
| MMP-1 | 48 | 120 (0–277.5) | 24 | 48.9 (0–285) | 50 | 147.5 (0–285) | 0.002 | 0.006 | 0 (0–204.4) |
| MMP-2 | 48 | 0 | 25 | 0 (0–121.2) | 50 | 0 (0–246) | n.s. | n.s. | 0 (0–94.8) |
| MMP-7 | 47 | 140.9 (0–258.4) | 25 | 0 (0–130.8) | 50 | 120 (0–270) | 0.0001 | 0.0001 | 0 (0–53.8) |
| MMP-9 | 50 | 64.5 (0–156) | 25 | 0 (0–52.2) | 49 | 108 (0–273) | 0.0001 | 0.01 | 36.2 (0–120.2)† |
| MMP-11 | 49 | 134 (0–279) | 24 | 121.3 (0–257.1) | 49 | 173 (0–277.7) | 0.002 | 0.0001 | 150.9 (0–275.1) |
| MMP-13 | 50 | 65.7 (0–234) | 22 | 45.19 (0–133.8) | 50 | 60.6 (0–192.3) | 0.05 | 0.05 | 44.9 (0–142.1) |
| MMP-14 | 50 | 81 (0–261) | 24 | 73.4 (0.279.8) | 50 | 85.3 (0–258.5) | 0.05 | n.s. | 59.7 (0–159.8) |
| TIMP-1 | 50 | 132 (0–258) | 24 | 116.6 (21.8–235.7) | 49 | 158 (0–285) | 0.0001 | 0.01 | 127.8 (28.2–217.2) |
| TIMP-2 | 50 | 72 (0–220) | 24 | 80.2 (0–211.8) | 49 | 142 (34–243) | 0.0001 | 0.01 | 101.6 (39.4–215.9) |
| TIMP-3 | 50 | 101.7 (0–284.8) | 24 | 53.1 (0–213.6) | 50 | 126.9 (0–253.3) | 0.03 | n.s. | 61.3 (0–268.2) |
n.s. not significant
* p values for comparing the three groups of primary tumors primary tumors
†0.006: local recurrence versus primary tumors of local recurrences (Wilcoxon test)